[18F]对甲基哌嗪氟苯：一种用于正电子发射断层扫描（PET）研究5-羟色胺（5-HT）1A受体的放射性标记拮抗剂。

[(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET.

作者信息

Plenevaux A, Lemaire C, Aerts J, Lacan G, Rubins D, Melega W P, Brihaye C, Degueldre C, Fuchs S, Salmon E, Maquet P, Laureys S, Damhaut P, Weissmann D, Le Bars D, Pujol J F, Luxen A

机构信息

Cyclotron Research Center, Liège University, Sart Tilman B.30, B-4000 Liège, Belgium.

出版信息

Nucl Med Biol. 2000 Jul;27(5):467-71. doi: 10.1016/s0969-8051(00)00113-x.

DOI:10.1016/s0969-8051(00)00113-x

PMID:10962252

Abstract

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.

摘要

本文总结了用[（18）F]4-（2'-甲氧基苯基）-1-[2'-[N-（2"-吡啶基）-对氟苯甲酰胺基]乙基]-哌嗪（即[（18）F]p-MPPF）开展研究的现状，[（18）F]p-MPPF是一种新型5-HT(1A)拮抗剂，用于正电子发射断层扫描（PET）研究血清素能神经传递。这包括化学、放射化学、动物数据（大鼠、猫和猴子）的放射自显影和PET研究、人体PET数据、毒性和代谢。