Moreau J F, Droz D, Sabto J, Jungers P, Kleinknecht D, Hinglais N, Michel J R
Radiology. 1975 May;115(2):329-36. doi: 10.1148/115.2.329.
Renal biopsies were performed in 211 patients which 10 days of excretory urography or renal arteriogrpahy in which diatrizoate, iothalamate or ioxithalamate had been used. In 47 renal specimens, osmotic nephrosis of the proximal tubular cells was found. Previous renal function had been normal in 10 patients, moderately impaired in 19, and severely impaired in 18. Tubular atrophy and/or necrosis was associated with histological features in 29 of 47 patients. Diffuse osmotic nephrosis was more often found in patients biopsied soon after roentgenography and also with severe renal insufficiency, but was not necessarily associated with declining renal function. The mechanism(s) by which contrast media may induce osmotic nephrosis remains unclear.
对211例患者进行了肾活检，这些患者在排泄性尿路造影或肾动脉造影检查后10天内使用了泛影葡胺、碘他拉酸盐或碘克沙酸盐。在47个肾标本中，发现近端肾小管细胞出现渗透性肾病。10例患者先前肾功能正常，19例中度受损，18例严重受损。47例患者中有29例肾小管萎缩和/或坏死与组织学特征相关。弥漫性渗透性肾病在放射检查后不久进行活检的患者中更常见，也与严重肾功能不全有关，但不一定与肾功能下降相关。造影剂可能诱发渗透性肾病的机制尚不清楚。
