Rosenberg J C, Lekas N, Lysz K, Morrell R
Surgery. 1975 Apr;77(4):520-9.
Human platelets suspended in autologous plasma do not respond to nonspecific immune complexes as do platelet suspensions from rabbits and dogs. However, platelets of all three species do undergo aggregation and the release reaction when exposed to antibodies directed against platelets. Antithymocyte globulin (ATG) contains such antibodies, apparently because of antigens common to both thymocytes and platelets. ATG-induced platelet aggregation and release is thus a specific reaction which may be responsible for the thrombocytopenia and thrombotic complications occasionally seen following the administration of ATG. However, if ATG is given properly, its effect on platelets should not constitute a contraindication to the use of this immunosuppressive drug. Since nonspecific immune complexes do not affect human platelets in the presence of plasma, it would appear that platelet aggregates seen in hyperacute and acute rejection result from endothelial damage rather than an effect of immune complexes on platelets.
悬浮于自体血浆中的人血小板对非特异性免疫复合物无反应，而兔和犬的血小板悬液则有反应。然而，当这三种物种的血小板暴露于针对血小板的抗体时，都会发生聚集和释放反应。抗胸腺细胞球蛋白（ATG）含有此类抗体，显然是因为胸腺细胞和血小板存在共同抗原。因此，ATG诱导的血小板聚集和释放是一种特异性反应，这可能是ATG给药后偶尔出现血小板减少和血栓形成并发症的原因。然而，如果正确使用ATG，其对血小板的影响不应构成使用这种免疫抑制药物的禁忌证。由于在血浆存在的情况下非特异性免疫复合物不影响人血小板，因此在超急性和急性排斥反应中见到的血小板聚集似乎是由内皮损伤引起的，而非免疫复合物对血小板的作用。
