血小板在兔急性血清病肾炎中的作用：双嘧达莫和FUT-175的保护作用
Platelet involvement in the nephritis of acute serum sickness in rabbits: protection by dipyridamole and FUT-175.
作者信息
Koyama A, Inage H, Sano M, Narita M, Tojo S, Neild G H, Cameron J S
出版信息
Clin Exp Immunol. 1985 Aug;61(2):388-96.
In the acute serum sickness model in rabbits, we investigated platelet release of 5-HT, platelet surface immunoglobulins, and platelet aggregation in response to ADP, together with the effect of dipyridamole and the Clr antagonist FUT-175. The immune release of 5-HT from platelets occurred between 4 and 6 days after injection of bovine serum albumin (BSA), before immune elimination and proteinuria, but coincident with the appearance of immune complexed BSA in the circulation. Nevertheless, platelet turnovers were not detectably accelerated. Treatment with dipyridamole 50 mg/kg/24 h prevented the release of 5-HT and inhibited proteinuria, glomerular hypercellularity and immune complexes in the glomeruli. Using the Clr antagonist FUT-175, similar abrogation of the disease was obtained. We conclude that in the nephritis of acute serum sickness in rabbits, some of the immune release from platelets may be the result of immune complex binding to the platelet, perhaps through the receptor for C3b.
在兔急性血清病模型中，我们研究了血小板5-羟色胺（5-HT）的释放、血小板表面免疫球蛋白以及血小板对二磷酸腺苷（ADP）的聚集反应，同时研究了双嘧达莫和补体C1r拮抗剂FUT-175的作用。血小板5-HT的免疫释放发生在注射牛血清白蛋白（BSA）后4至6天，在免疫清除和蛋白尿出现之前，但与循环中免疫复合物结合的BSA的出现同时发生。然而，血小板周转率并未明显加快。以50mg/kg/24h的剂量给予双嘧达莫治疗可阻止5-HT的释放，并抑制蛋白尿、肾小球细胞增多以及肾小球中的免疫复合物。使用补体C1r拮抗剂FUT-175也可获得类似的疾病缓解效果。我们得出结论，在兔急性血清病肾炎中，血小板的一些免疫释放可能是免疫复合物与血小板结合的结果，可能是通过C3b受体。
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