白细胞增多与HELLP综合征严重程度成正比：子痫前期炎症形式的证据。

Leukocytosis is proportional to HELLP syndrome severity: evidence for an inflammatory form of preeclampsia.

作者信息

Terrone D A, Rinehart B K, May W L, Moore A, Magann E F, Martin J N

机构信息

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.

出版信息

South Med J. 2000 Aug;93(8):768-71.

PMID:10963506

Abstract

BACKGROUND

We investigated the possibility that HELLP syndrome is in part a systemic inflammatory response.

METHODS

We evaluated total white blood cell (WBC) counts of all patients with severe preeclampsia with and without HELLP syndrome admitted to our hospital between 1995 and 1997. Patients were grouped by diagnosis and timing of platelet nadir. Analysis of variance and regression analysis were used for data analysis.

RESULTS

Of 177 patients, 91 had HELLP syndrome, and 86 had severe preeclampsia alone. The WBC counts were significantly higher in patients with HELLP syndrome (12.5 +/- .442 x 10(9)/L) than in patients with severe preeclampsia (10.3 +/- .288 x 10(9)/L). Regression analysis showed that platelet counts varied inversely with WBC counts. Also, patients with class I HELLP syndrome had significantly higher WBC counts than patients with other classes of HELLP syndrome.

CONCLUSION

The finding of an association between increasing leukocytosis and worsening thrombocytopenia early in the course of HELLP syndrome supports the hypothesis that it may represent an inflammatory process.

摘要

背景

我们研究了HELLP综合征部分是一种全身炎症反应的可能性。

方法

我们评估了1995年至1997年间入住我院的所有重度子痫前期患者（无论有无HELLP综合征）的白细胞（WBC）总数。患者按诊断和血小板最低点出现时间分组。采用方差分析和回归分析进行数据分析。

结果

177例患者中，91例患有HELLP综合征，86例仅患有重度子痫前期。HELLP综合征患者的白细胞计数（12.5±0.442×10⁹/L）显著高于重度子痫前期患者（10.3±0.288×10⁹/L）。回归分析表明血小板计数与白细胞计数呈负相关。此外，I级HELLP综合征患者的白细胞计数显著高于其他级别的HELLP综合征患者。