Wang Xi, Zhang Yang-Yang, Xu Yang
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.
World J Clin Cases. 2022 Dec 26;10(36):13349-13355. doi: 10.12998/wjcc.v10.i36.13349.
Pregnancy is a complex physiological process. Physiological leukocytosis occurs often and is mainly associated with increased neutrophil counts, especially in the third trimester of pregnancy. Non-congenital leukocytosis with white blood cell counts above 20 × 10/L lasting 13 wk during pregnancy is rare and has been reported occasionally. Herein, we present a case of pregnancy-induced leukocytosis.
We present the case of a 33-year-old Chinese woman at 27 wk of gestation who had a leukocytosis complication. No abnormalities were detected in the examinations before pregnancy or in the first trimester. From the third trimester of pregnancy, the patient began to suffer from asymptomatic leukocytosis. We administered antibiotics to treat the patient; however, the complication persisted until the patient underwent a cesarean section after 40 wk of gestation. One day after the cesarean section, the patient's neutrophil count returned to normal. After 2 years of follow-up, we found that the patient and baby were healthy.
Pregnancy-induced leukocytosis seems to be associated with immunoregulation and pregnancy termination may be the most effective treatment approach for pregnancies complicated with malignant leukocytosis.
妊娠是一个复杂的生理过程。生理性白细胞增多症较为常见,主要与中性粒细胞计数增加有关,尤其是在妊娠晚期。孕期白细胞计数高于20×10⁹/L且持续13周的非先天性白细胞增多症较为罕见,仅有偶尔的病例报道。在此,我们报告一例妊娠诱发的白细胞增多症病例。
我们报告一例33岁中国女性,孕27周时出现白细胞增多症并发症。孕前及孕早期检查均未发现异常。从妊娠晚期开始,患者出现无症状性白细胞增多症。我们给予患者抗生素治疗,但并发症持续存在,直至患者孕40周行剖宫产术后。剖宫产术后一天,患者中性粒细胞计数恢复正常。经过2年随访,我们发现患者和婴儿均健康。
妊娠诱发的白细胞增多症似乎与免疫调节有关,对于合并恶性白细胞增多症的妊娠,终止妊娠可能是最有效的治疗方法。