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人类胎儿气管和肺在免疫缺陷小鼠体内的生长与发育。

Growth and development of human fetal trachea and lung in immune-deprived mice.

作者信息

Cobb L M

出版信息

Thorax. 1975 Jun;30(3):357-9. doi: 10.1136/thx.30.3.357.

DOI:10.1136/thx.30.3.357
PMID:1096353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC470293/
Abstract

Trachea and lung parenchyma from human fetuses were transplanted subcutaneously into immune-deprived mice. After seven to 10 weeks they were removed for histological examination. It was found that the tissues continued to grow and develop along similar lines to those which they would have followed in utero.

摘要

将人类胎儿的气管和肺实质皮下移植到免疫缺陷小鼠体内。7至10周后，将其取出进行组织学检查。结果发现，这些组织继续沿着与在子宫内相同的路线生长和发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fa/470293/9b146d6aedc1/thorax00141-0118-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fa/470293/6f548e39b68e/thorax00141-0118-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fa/470293/9b146d6aedc1/thorax00141-0118-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fa/470293/6f548e39b68e/thorax00141-0118-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70fa/470293/9b146d6aedc1/thorax00141-0118-b.jpg

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本文引用的文献

1
The culture of mature organs in a synthetic medium.在合成培养基中对成熟器官进行培养。
Exp Cell Res. 1959 Jan;16(1):118-47. doi: 10.1016/0014-4827(59)90201-0.
2
Further observations on the use of organ cultures in the study of acute respiratory-tract infections.关于器官培养在急性呼吸道感染研究中的应用的进一步观察。
J Med Microbiol. 1973 May;6(2):177-85. doi: 10.1099/00222615-6-2-177.
3
An organ culture study of the effect of drugs on the secretory activity of the human bronchial submucosal gland.药物对人支气管黏膜下腺分泌活性影响的器官培养研究
先天性人巨细胞病毒感染的 SCID-hu 肺鼠模型中肺泡上皮细胞表面活性剂生成受损。
J Virol. 2012 Dec;86(23):12795-805. doi: 10.1128/JVI.01054-12. Epub 2012 Sep 12.
4
The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung.人胎肺异种移植：在后腺肺中作为微血管重构模型的验证。
Pediatr Pulmonol. 2012 Dec;47(12):1192-203. doi: 10.1002/ppul.22617. Epub 2012 Jul 18.
5
Differentiation of xenografted human fetal lung parenchyma.异种移植的人胎儿肺实质的分化
Early Hum Dev. 2008 Mar;84(3):181-93. doi: 10.1016/j.earlhumdev.2007.04.002. Epub 2007 Jun 6.
Clin Sci. 1972 Oct;43(4):533-43. doi: 10.1042/cs0430533.
4
The growth of human tumours in immune deprived mice.
Eur J Cancer (1965). 1974 Aug;10(8):473-6. doi: 10.1016/0014-2964(74)90068-1.
5
Developmental aspects of the human lung.人类肺部的发育方面
Pediatr Clin North Am. 1973 May;20(2):275-92. doi: 10.1016/s0031-3955(16)32843-7.
6
The behaviour of carcinoma of the large bowel in man following transplantation into immune deprived mice.人大肠癌移植到免疫缺陷小鼠后的行为表现。
Br J Cancer. 1973 Nov;28(5):400-11. doi: 10.1038/bjc.1973.165.
7
Survival of skin heterografts under treatment with antilymphocytic serum.
Lancet. 1968 Jun 1;1(7553):1174-6. doi: 10.1016/s0140-6736(68)91868-0.