Sasazuki S, Kodama H, Yoshimasu K, Liu Y, Washio M, Tanaka K, Tokunaga S, Kono S, Arai H, Doi Y, Kawano T, Nakagaki O, Takada K, Koyanagi S, Hiyamuta K, Nii T, Shirai K, Ideishi M, Arakawa K, Mohri M, Takeshita A
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ann Epidemiol. 2000 Aug;10(6):401-8. doi: 10.1016/s1047-2797(00)00066-1.
To examine the relation between green tea consumption and arteriographically determined coronary atherosclerosis.
Study subjects were 512 patients (302 men and 210 women) aged 30 years or older who underwent coronary arteriography for the first time at four hospitals in Fukuoka City or one hospital in an adjacent city between September 1996 and August 1997. Lifestyle characteristics including green tea consumption were ascertained before arteriography by a questionnaire supported with interview.
117 men (38.7%) and 50 women (23.8%) had significant stenosis of one or more coronary arteries. Green tea consumption tended to be inversely associated with coronary atherosclerosis in men, but not in women. An evident, protective association between green tea and coronary atherosclerosis was observed in a subgroup of 262 men excluding those under dietary or drug treatment for diabetes mellitus. In this subgroup, after adjustment for traditional coronary risk factors and coffee, odds ratios of significant stenosis for consumption of 2-3 cups and 4 or more cups per day were 0.5 (95% confidence interval 0.2-1.2) and 0.4 (0.2-0.9), respectively, as compared with a consumption of one cup per day or less.
The results indicate that green tea may be protective against coronary atherosclerosis at least in men.
研究绿茶摄入量与冠状动脉造影确定的冠状动脉粥样硬化之间的关系。
研究对象为512例年龄30岁及以上的患者（302例男性和210例女性），他们于1996年9月至1997年8月期间在福冈市的四家医院或相邻城市的一家医院首次接受冠状动脉造影。在冠状动脉造影前，通过问卷调查并辅以访谈来确定包括绿茶摄入量在内的生活方式特征。
117例男性（38.7%）和50例女性（23.8%）存在一支或多支冠状动脉的显著狭窄。男性中绿茶摄入量与冠状动脉粥样硬化呈负相关趋势，而女性中未观察到这种关系。在排除接受糖尿病饮食或药物治疗的男性后的262名男性亚组中，观察到绿茶与冠状动脉粥样硬化之间存在明显的保护关联。在该亚组中，在调整传统冠状动脉危险因素和咖啡摄入量后，每天饮用2 - 3杯和4杯及以上绿茶的患者出现显著狭窄的比值比分别为0.5（95%置信区间0.2 - 1.2）和0.4（0.2 - 0.9），而每天饮用一杯或更少的患者作为对照。
结果表明绿茶可能至少对男性冠状动脉粥样硬化具有保护作用。
