日本健康工作者群体中绿茶摄入量与血清脂质及脂蛋白的关系

Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan.

作者信息

Tokunaga Shoji, White Ian R, Frost Chris, Tanaka Keitaro, Kono Suminori, Tokudome Shinkan, Akamatsu Takashi, Moriyama Takeshi, Zakouji Hidemoto

机构信息

Department of Preventive Medicine, Graduate School of Medical School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Ann Epidemiol. 2002 Apr;12(3):157-65. doi: 10.1016/s1047-2797(01)00307-6.

DOI:10.1016/s1047-2797(01)00307-6

PMID:11897173

Abstract

PURPOSE

To examine the relation between green tea consumption and serum lipids and lipoproteins.

METHODS

The subjects were 13,916 workers (8476 men and 5440 women) aged 40-69 years at over 1000 workplaces in Nagano prefecture, central Japan. They underwent health screening offered by a single medical institute between April 1995 and March 1996 and did not have morbid conditions affecting serum cholesterol levels. Serum concentrations of total cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides were measured at the screening. The consumption of green tea and other life-style characteristics were ascertained by a questionnaire. The data were analyzed with multivariate linear model.

RESULTS

Daily consumption of green tea was reported by 86.7% of subjects. Green tea consumption was, statistically, significantly associated with lower levels of serum total cholesterol in both men and women while its associations with serum triglycerides and HDL cholesterol were not statistically significant. The inverse association of serum total cholesterol with green tea consumption appeared to level off at the consumption of more than 10 cups/day. Excluding the outlying subjects drinking more than 10 cups/day (0.4%), the regression analysis adjusting for age, body mass index, ethanol intake, smoking habit, coffee intake, and type of work showed that daily consumption of one cup of green tea was associated with a reduction in serum total cholesterol by 0.015 mmol/L (95% confidence interval 0.006 to 0.024, p < 0.001) in men and 0.015 mmol/L (0.004 to 0.025, p < 0.01) in women. After additional adjustment for selected dietary factors, the inverse association remained statistically significant; one cup of green tea per day was associated with a reduction in serum total cholesterol by 0.010 mmol/L (0.001 to 0.019, p = 0.03) in men and 0.012 mmol/L (0.001 to 0.022, p = 0.03) in women.

CONCLUSION

Consumption of green tea was associated with lower serum concentration of total cholesterol in Japanese healthy workers age 40-69 years; however, green tea consumption was unrelated to serum HDL-cholesterol and triglycerides.

摘要

目的

研究绿茶摄入量与血清脂质及脂蛋白之间的关系。

方法

研究对象为日本中部长野县1000多个工作场所的13916名年龄在40 - 69岁的工人（8476名男性和5440名女性）。他们于1995年4月至1996年3月期间在一家医疗机构接受了健康筛查，且没有影响血清胆固醇水平的疾病。在筛查时测量了血清总胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯的浓度。通过问卷调查确定绿茶摄入量及其他生活方式特征。数据采用多元线性模型进行分析。

结果

86.7%的研究对象报告有每日饮用绿茶的习惯。从统计学角度来看，绿茶摄入量与男性和女性血清总胆固醇水平较低显著相关，而与血清甘油三酯和HDL胆固醇的相关性无统计学意义。血清总胆固醇与绿茶摄入量之间的负相关在每日饮用超过10杯时似乎趋于平稳。排除每日饮用超过10杯绿茶的极端研究对象（0.4%）后，在对年龄、体重指数、乙醇摄入量吸烟习惯、咖啡摄入量和工作类型进行校正的回归分析中，结果显示男性每日饮用一杯绿茶与血清总胆固醇降低0.015 mmol/L相关（95%置信区间0.006至0.024，p < 0.001），女性为0.015 mmol/L（0.004至0.025，p < 0.01）。在对选定饮食因素进行进一步校正后，这种负相关仍具有统计学意义；男性每日一杯绿茶与血清总胆固醇降低0.010 mmol/L相关（0.001至0.019，p = 0.03），女性为0.012 mmol/L（0.001至0.022，p = 0.03）。