Gu Z, Gilbert D J, Valentine V A, Jenkins N A, Copeland N G, Zambetti G P
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis TN, USA.
Cytogenet Cell Genet. 2000;89(3-4):230-3. doi: 10.1159/000015620.
Activation of the p53 tumor suppressor leads to either a cell cycle arrest or to apoptosis and the factors that influence these responses are poorly understood. It is clear, however, that p53 regulates these processes by inducing a series of downstream target genes. One recently identified p53-target gene, EI24 (alias PIG8), induces apoptosis when ectopically expressed. To better understand the biological properties of EI24 and its potential relevance to disease, in particular cancer, we determined the chromosomal location and pattern of gene expression of EI24. EI24 is widely expressed in adult tissues and throughout mouse embryogenesis. The genomic locus of EI24 was mapped to the proximal region of mouse chromosome 9 and human chromosome 11q23-->q24, a region frequently altered in human cancers. These results suggest that EI24 may play an important role in the p53 tumor suppressor pathway.
p53肿瘤抑制因子的激活会导致细胞周期停滞或凋亡，而影响这些反应的因素目前还知之甚少。然而，很明显，p53通过诱导一系列下游靶基因来调节这些过程。最近发现的一个p53靶基因EI24（别名PIG8），在异位表达时会诱导细胞凋亡。为了更好地了解EI24的生物学特性及其与疾病尤其是癌症的潜在关联，我们确定了EI24的染色体定位和基因表达模式。EI24在成年组织以及整个小鼠胚胎发育过程中广泛表达。EI24的基因组位点被定位到小鼠9号染色体的近端区域以及人类11号染色体的11q23→q24区域，该区域在人类癌症中经常发生改变。这些结果表明，EI24可能在p53肿瘤抑制途径中发挥重要作用。
