皮质基底节变性和克雅氏病患者中气球样神经元的高尔基体碎片化。

Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease.

作者信息

Sakurai A, Okamoto K, Fujita Y, Nakazato Y, Wakabayashi K, Takahashi H, Gonatas N K

机构信息

Department of Neurology, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Acta Neuropathol. 2000 Sep;100(3):270-4. doi: 10.1007/s004010000182.

DOI:10.1007/s004010000182

PMID:10965796

Abstract

We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.

摘要

我们对两名皮质基底节变性患者和五名克雅氏病患者的皮质气球样神经元（BNs）的高尔基体（GA）和反式高尔基体网络（TGN）进行了免疫组织学研究。我们观察到，BNs显示出GA和TGN的碎片化，伴随着碎片化高尔基体元件数量的减少以及独特的核周分布。这是关于皮质BNs中GA异常的首次报道。这些发现表明，GA和TGN可能在BNs的形成中发挥一些作用。