Hammond S A, Tsonis C, Sellins K, Rushlow K, Scharton-Kersten T, Colditz I, Glenn G M
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, RM 2W-124, 503 Robert Grant Avenue, Washington, DC 20307-5100, USA.
Adv Drug Deliv Rev. 2000 Sep 15;43(1):45-55. doi: 10.1016/s0169-409x(00)00076-4.
Transcutaneous immunization (TCI), the topical application of antigen and adjuvant directly onto intact skin, can safely and effectively elicit systemic immune responses in mice and humans against a variety of antigens. This novel method of vaccine delivery has the potential to provide a safe and convenient method by which vaccines may be delivered to elicit protective immunity in domestic animals. To date, however, immune responses induced by TCI in companion and production animals has not been reported. In this report, we demonstrate that TCI may be widely applicable to many animals. Immune responses elicited by TCI require further optimization for each antigen and species, and success may depend upon the structure and composition of the skin of the target species. The prospect of TCI as a practical and broadly applicable approach to vaccination in veterinary medicine is discussed in the context of these challenges.
经皮免疫（TCI），即将抗原和佐剂直接局部应用于完整皮肤，可在小鼠和人类中安全有效地引发针对多种抗原的全身免疫反应。这种新型疫苗递送方法有可能提供一种安全便捷的方式，通过它可递送疫苗以在家畜中引发保护性免疫。然而，迄今为止，尚未有关于TCI在伴侣动物和生产动物中诱导免疫反应的报道。在本报告中，我们证明TCI可能广泛适用于许多动物。TCI引发的免疫反应需要针对每种抗原和物种进一步优化，其成功可能取决于目标物种皮肤的结构和组成。在这些挑战的背景下，讨论了TCI作为兽医学中一种实用且广泛适用的疫苗接种方法的前景。
