Celis J E, Kruhøffer M, Gromova I, Frederiksen C, Ostergaard M, Thykjaer T, Gromov P, Yu J, Pálsdóttir H, Magnusson N, Orntoft T F
Department of Medical Biochemistry and Danish Centre for Human Genome Research, University of Aarhus, Denmark.
FEBS Lett. 2000 Aug 25;480(1):2-16. doi: 10.1016/s0014-5793(00)01771-3.
Novel and powerful technologies such as DNA microarrays and proteomics have made possible the analysis of the expression levels of multiple genes simultaneously both in health and disease. In combination, these technologies promise to revolutionize biology, in particular in the area of molecular medicine as they are expected to reveal gene regulation events involved in disease progression as well as to pinpoint potential targets for drug discovery and diagnostics. Here, we review the current status of these technologies and highlight some studies in which they have been applied in concert to the analysis of biopsy specimens.
诸如DNA微阵列和蛋白质组学等新颖且强大的技术，使得同时分析健康和疾病状态下多个基因的表达水平成为可能。这些技术相结合，有望给生物学带来变革，尤其是在分子医学领域，因为它们有望揭示疾病进展过程中涉及的基因调控事件，以及确定药物研发和诊断的潜在靶点。在此，我们综述这些技术的现状，并重点介绍一些将它们协同应用于活检标本分析的研究。
