Tsoka S, Ouzounis C A
Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, UK.
FEBS Lett. 2000 Aug 25;480(1):42-8. doi: 10.1016/s0014-5793(00)01776-2.
Computational genomics is a subfield of computational biology that deals with the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent properties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approaches that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies.
计算基因组学是计算生物学的一个子领域，致力于分析整个基因组序列。计算基因组学超越了传统序列分析的界限，通过将整个基因组建模为系统来利用其内在特性。我们回顾了该领域的最新进展，详细讨论了一些考虑基因组背景的新方法，并认为新知识表示和模拟技术将推动该领域取得进展。
