Andrade Cetto A, Wiedenfeld H, Revilla M C, Sergio I A
Biological Department, Science School, National University of México UNAM, DF., 04510 México, Mexico.
J Ethnopharmacol. 2000 Sep;72(1-2):129-33. doi: 10.1016/s0378-8741(00)00218-x.
The hypoglycemic effect of water as well as butanolic extracts prepared from aerial parts of Equisetum myriochaetum (Equisetaceae) was examined in streptozotocin induced diabetic rats. A single oral administration of the water extract (WE) at doses of 7 and 13 mg/kg and of the butanol extract (BE) at doses of 8 and 16 mg/kg significantly (P<0.001) lowered the plasma glucose levels in diabetic rats after three hours of the administration. As a reference drug glibenclamide was used and showed, at a dose of 3 mg/kg, similar hypoglycemic effect like the tested extracts. Three kaempferol glucosides and one caffeoyl glucoside were isolated from the drug and were shown to be the main constituents in both extracts.
研究了木贼科多枝木贼地上部分制备的水提取物和丁醇提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖作用。单次口服7和13 mg/kg剂量的水提取物（WE）以及8和16 mg/kg剂量的丁醇提取物（BE），给药三小时后能显著（P<0.001）降低糖尿病大鼠的血糖水平。作为对照药物，使用了格列本脲，其3 mg/kg的剂量显示出与受试提取物相似的降血糖作用。从该药物中分离出三种山奈酚糖苷和一种咖啡酰糖苷，它们是两种提取物中的主要成分。
