Holmberg L, Nilsson I M
Annu Rev Med. 1975;26:33-44. doi: 10.1146/annurev.me.26.020175.000341.
The common inheritable hemorrhagic disorder, von Willebrand's disease, has been known for only about 50 yr. During these years it has been well established that the cause of the disease is a deficiency of a plasma protein with remarkable biological properties. Future research should focus on details of the molecular structure of this protein. It is hoped that basic science will help to elucidate those aspects of von Willebrand's disease that are not yet properly understood.
