Machet G, Coudray J M
Service Pharmacie, Centre hospitalier Lagny-Marne-la-Vallée, France.
Therapie. 2000 Mar-Apr;55(2):283-94.
In type II diabetes treated with metformin (Glucophage) lactic acidosis is a rare adverse reaction, fatal in approximately 50 per cent of cases. Metformin is implicated by plasma and intra-erythrocyte levels. An analysis is carried out on available information about this risk for healthcare professionals and for patients. A comparison is made of approved labelling information on Glucophage and its patient leaflets in France and in the USA and an analysis made of the differences. In France, Information given to physicians, pharmacists and patients on the risk of lactic acidosis where Glucophage is implicated must be improved, and on the interest of the metformin plasma level in this case. These are primary points because the issue for the few patients concerned may be fatal. Advice on self-medication may be introduced. The evolution of information provided on these risks depends on the pharmaceutical laboratory, government authorities and healthcare professionals.
在使用二甲双胍（格华止）治疗的II型糖尿病患者中，乳酸酸中毒是一种罕见的不良反应，约50%的病例会致命。血浆和红细胞内水平与二甲双胍有关。针对这一风险，对医疗保健专业人员和患者可获取的信息进行了分析。比较了法国和美国格华止的批准标签信息及其患者说明书，并分析了其中的差异。在法国，必须改进向医生、药剂师和患者提供的有关格华止引发乳酸酸中毒风险的信息，以及在这种情况下二甲双胍血浆水平的意义。这些是要点，因为对少数相关患者来说，这个问题可能是致命的。可以引入自我用药建议。关于这些风险的信息演变取决于制药实验室、政府当局和医疗保健专业人员。
