Sharma B L, Rani R, Misra R, Aggarwal A
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
Indian J Med Res. 2000 Jun;111:215-8.
As the proportion of patients with rheumatoid arthritis (RA) who have anti-keratin antibodies (AKA) varies in different ethnic groups, we studied its occurrence in a hospital populations with RA and its association with different disease variables. Sera from 84 consecutive patients with RA, 100 healthy controls and 85 disease controls (polyarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis) were tested for AKA by an indirect immunofluorescence assay that used rat esophagus as substrate. The proportion of patients with RA who had AKA (47/84) was higher than in healthy controls (2/100; P < 0.001) and in disease controls (2/85; P < 0.001). The frequency of AKA positivity was higher among patients who had severe disease (P < 0.05) and rheumatoid factor. Anti-keratin antibody is present in 56 per cent of our patients with RA and is associated with severe disease.
由于类风湿性关节炎（RA）患者中抗角蛋白抗体（AKA）的比例在不同种族群体中有所不同，我们研究了其在一家医院的RA患者群体中的发生率及其与不同疾病变量的关联。通过以大鼠食管为底物的间接免疫荧光试验，对84例连续的RA患者、100例健康对照者和85例疾病对照者（多关节型幼年类风湿性关节炎、系统性红斑狼疮、强直性脊柱炎）的血清进行AKA检测。患有AKA的RA患者比例（47/84）高于健康对照者（2/100；P<0.001）和疾病对照者（2/85；P<0.001）。在患有严重疾病（P<0.05）和类风湿因子的患者中，AKA阳性频率更高。我们的RA患者中有56%存在抗角蛋白抗体，且其与严重疾病相关。
