Emery J L, Dinsdale F
Biol Neonate. 1975;26(1-2):44-52. doi: 10.1159/000240715.
A survey has been carried out of lymphoreticular aggregates in the lungs of 200 children, stillborns and dying within 15 days of birth and in a further 21 children with anencephalus, and controls. Lymphoreticular aggregates occur in response to amniotic infection and are found in the 'intrauterine infection syndrome'. They are not found in children showing early hyaline membranes. The time interval required for the production of lymphoreticular aggregates in the human child appears to be at lease 48 h and is probably 72 h before the production of well-formed aggregates and this probably applies to both the intrauterine and the postnatal state. There is a significant increase in the number of lungs showing lymphoreticular aggregates at birth in children in whom there is neurospinal dysraphism. In such children there is necrosis of nervous tissue into the amniotic cavity and it would seem likely that this material has been antigenic to the lung in utero.
对200名死产儿及出生后15天内死亡的儿童、另外21名无脑儿以及对照组儿童的肺部淋巴网状聚集体进行了一项调查。淋巴网状聚集体是对羊膜腔感染的反应，见于“宫内感染综合征”。在出现早期透明膜的儿童中未发现此类聚集体。人类儿童产生淋巴网状聚集体所需的时间间隔似乎至少为48小时，形成良好聚集体之前可能为72小时，这可能适用于宫内和出生后状态。在患有神经管闭合不全的儿童中，出生时肺部出现淋巴网状聚集体的数量显著增加。在这类儿童中，神经组织会坏死进入羊膜腔，这种物质在子宫内似乎对肺部具有抗原性。
