Takahata H, Okamoto N
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Sugitani, Japan.
Bioorg Med Chem Lett. 2000 Aug 21;10(16):1799-801. doi: 10.1016/s0960-894x(00)00341-3.
The total synthesis of piclavines A1, A2, A3, and A4 has been achieved starting from compound 10 with enantiomeric enhancement. Their biological activities (antibacterial, antimicrobacterial, and antiviral activities and inhibition of cell growth) were evaluated.
已从化合物10开始，通过对映体增强实现了匹克拉文A1、A2、A3和A4的全合成。评估了它们的生物活性（抗菌、抗微生物和抗病毒活性以及对细胞生长的抑制作用）。
