Saad H E, el-Sharkawy S H, Shier W T
Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Egypt.
Planta Med. 1995 Aug;61(4):313-6. doi: 10.1055/s-2006-958090.
Certain genera of the tribe Psychotrieae, specifically Calycodendron and Psychotria, found on Pacific Islands, synthesize a series of Nb-methyltryptamine-derived alkaloids made by linking together 2 to 8 pyrrolidinoindoline units. Nine alkaloids of this class have been isolated from the aerial parts and stem bark of Calycodendron milnei, a species endemic to the Vaté Islands (New Hebrides), and examined for potential application as anti-cancer and anti-infective agents. All members of the series exhibited readily detected cytotoxic activity against proliferating and non-proliferating Vero African green monkey kidney cells in culture, with the most potent activity being exhibited by vatamine and quadrigemine C. Only hodgkinsine A exhibited substantial antiviral activity against a DNA virus, herpes simplex type 1, and an RNA virus, vesicular stomatitis virus. All members of the series showed readily detected anti-bacterial, anti-fungal, and anti-candidal activities using both tube dilution and disc diffusion assay methods. The most potent anti-microbial alkaloids were hodgkinsine A and quadrigemine C, which exhibited minimum inhibitory concentration (MIC) values as low as 5 micrograms/ml.
在太平洋岛屿上发现的 Psychotrieae 族的某些属，特别是 Calycodendron 和 Psychotria，能合成一系列由 Nb - 甲基色胺衍生的生物碱，这些生物碱是通过将2至8个吡咯烷基吲哚啉单元连接在一起形成的。从瓦泰群岛（新赫布里底群岛）特有的物种 Calycodendron milnei 的地上部分和茎皮中分离出了该类别的9种生物碱，并对其作为抗癌和抗感染剂的潜在应用进行了研究。该系列的所有成员在培养物中对增殖和非增殖的非洲绿猴肾细胞（Vero细胞）均表现出易于检测到的细胞毒性活性，其中瓦他明和四联胺C表现出最强的活性。只有霍奇金辛A对DNA病毒单纯疱疹病毒1型和RNA病毒水疱性口炎病毒表现出显著的抗病毒活性。使用试管稀释法和纸片扩散法检测发现，该系列的所有成员均表现出易于检测到的抗菌、抗真菌和抗念珠菌活性。最有效的抗微生物生物碱是霍奇金辛A和四联胺C，其最低抑菌浓度（MIC）值低至5微克/毫升。
