Murakami N, Wang W, Tamura S, Kobayashi M
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Bioorg Med Chem Lett. 2000 Aug 21;10(16):1823-6. doi: 10.1016/s0960-894x(00)00356-5.
The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility.
