沙海葵毒素A的全合成改进及其构效关系研究，沙海葵毒素A是一种具有强细胞毒性的海绵来源环肽。
Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean depsipeptide.
作者信息
Kobayashi M, Wang W, Ohyabu N, Kurosu M, Kitagawa I
机构信息
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1995 Sep;43(9):1598-600. doi: 10.1248/cpb.43.1598.
PMID:7586087
Abstract
An efficient asymmetric synthesis of a cyclic depsipeptide arenastatis A (1) is described. 1, isolated from the marine sponge Dysidea arenaria, exhibited extremely potent cytotoxicity with IC50 of pg/ml for KB cells, and in this context the structure-activity relationship among several stereoisomers of 1 and allied compounds has also been examined.
摘要
本文描述了环缩肽沙海蛰素A（1）的高效不对称合成。沙海蛰素A（1）是从海洋海绵沙海蛰中分离得到的，对KB细胞表现出极强的细胞毒性，其IC50为pg/ml，在此背景下，还研究了1及其相关化合物的几种立体异构体之间的构效关系。
Zotero 插件