Terblanche J, Hickman R, Uys C J
Br J Surg. 1975 Jun;62(6):474-9. doi: 10.1002/bjs.1800620612.
A series of 82 kidney allografts and autografts in unimmunosuppressed pigs surviving for longer than 5 days has been compared with a previously reported series of 24 unimmunosuppressed pig kidney allografts. In the previous series 40 per cent survived for longer than 20 days. In the present series only 2 per cent of 55 transplants performed in cross-bred pigs obtained from different farms survived for longer than 20 days. The major causes of death were unrelated to rejection, prinicipally gastric ulcer bleeding. In the further 16 transplants between different pure-bred animals (thereby ensuring genetic disparity) the ulcer incidence was lowered by a gastro-enterostomy, and 12 per cent survived for longer than 20 days. Histological assessment of rejection in the latter group revealed 20 per cent with minimal rejection, was considered insufficient to account for the death of the animals. Based on the evaluation of 95 unimmunosuppressed pig kidney allografts in both series, it is concluded that a wide and unpredictable range of survival time occurs. Therefore the pig kidney allograft model is an unsatisfactory model in which to study immunosuppressive régimes. Also the unimmunosuppressed pig appears to show less evidence of kidney allograft rejection than the dog, irrespective of genetic disparity. It is tentatively suggested that this might be a lesser manifestation of the unexplained phenomenon of minimal rejection of liver allografts noted in unimmunosuppressed pigs.
对82例在未免疫抑制的猪身上存活超过5天的同种异体肾移植和自体肾移植进行了一系列研究，并与之前报道的24例未免疫抑制的猪同种异体肾移植进行了比较。在之前的系列研究中，40%的移植肾存活超过20天。在本系列研究中，从不同农场获得的杂交猪进行的55例移植中，只有2%存活超过20天。死亡的主要原因与排斥反应无关，主要是胃溃疡出血。在另外16例不同纯种动物之间的移植（从而确保基因差异）中，通过胃肠吻合术降低了溃疡发生率，12%存活超过20天。对后一组排斥反应的组织学评估显示，20%有轻微排斥反应，被认为不足以解释动物的死亡。基于对两个系列中95例未免疫抑制的猪同种异体肾移植的评估，得出结论：存活时间范围广泛且不可预测。因此，猪同种异体肾移植模型是研究免疫抑制方案的一个不理想模型。此外，无论基因差异如何，未免疫抑制的猪似乎比狗表现出更少的肾同种异体移植排斥证据。初步认为，这可能是未免疫抑制的猪中肝同种异体移植轻微排斥这一无法解释现象的一种较轻表现。
