Blumenkrantz M J, Shapiro D J, Swendseid M E, Kopple J D
Br Med J. 1975 Jun 7;2(5970):530-3. doi: 10.1136/bmj.2.5970.530.
The effects of supplemental histidine on the anaemia of 16 chronically uraemic patients and 26 patients undergoing maintenance dialysis were assessed. Patients were given either L-histidine 4 g/day or placebo for a mean of 17-5 weeks in a randomized double-blind controlled study. Haemoglobin and packed cell volume increased slightly and to a similar degree in the patients on dialysis receiving placebo and histidine, but this change was statistically significant only in those on placebo. Plasma histidine rose significantly in the histidine-treated patients undergoing dialysis and decreased in the uraemic patients receiving placebo. These results suggest that supplementary L-histidine in patients with uraemia or patients undergoing maintenance dialysis does not improve anaemia.
评估了补充组氨酸对16例慢性尿毒症患者和26例维持性透析患者贫血的影响。在一项随机双盲对照研究中，患者接受4克/天的L-组氨酸或安慰剂，平均治疗17.5周。接受安慰剂和组氨酸的透析患者的血红蛋白和红细胞压积略有增加，且程度相似，但这种变化仅在接受安慰剂的患者中具有统计学意义。接受组氨酸治疗的透析患者血浆组氨酸显著升高，而接受安慰剂的尿毒症患者血浆组氨酸降低。这些结果表明，尿毒症患者或维持性透析患者补充L-组氨酸并不能改善贫血。
