Bråthen G, Brodtkorb E, Sand T, Helde G, Bovim G
Department of Clinical Neurosciences, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim.
Eur J Neurol. 2000 Jul;7(4):413-21. doi: 10.1046/j.1468-1331.2000.00097.x.
Binge drinking at weekends is considered to be a predominant feature of alcohol consumption in the Nordic countries. Neurological diseases, such as seizures and stroke, have been reported to occur in temporal relation to alcohol intoxication and withdrawal. We wanted to investigate weekday variances in alcohol consumption in relation to the onset of neurological symptoms in these disorders. Consecutive patients admitted for epileptic seizures (n = 142) and ischemic strokes (n = 91) were included in the study. Control groups were consecutively hospitalized sciatica patients (n = 181), outpatients with epilepsy (n = 91), and healthy subjects (n = 254). The day-by-day alcohol intake during the 8 days prior to hospital admission was recorded. Seizures occurring in subjects with hazardous alcohol consumption, operationally defined by a score > or =8 in the Alcohol Use Disorders Identification Test (AUDIT-positive) were considered to be related to alcohol use. Binge drinkers were identified by an alcohol intake, on at least 1 of the last 3 days, of > or =6 standard units in men, or > or =4 standard units in women. Thirty-five percent of seizure patients were AUDIT-positive, in contrast to 18% and 16% of stroke and sciatica patients, and 12% and 13% of epilepsy outpatients and healthy controls. Twenty-three percent of seizure patients were binge drinkers whereas in the other groups, this proportion did not exceed 10%. In all groups, alcohol consumption peaked on Saturdays. More seizures occurred on Mondays compared to Saturdays, with a diminishing trend through the week. However, AUDIT-negative seizure patients, of which binge drinking occurred in only 5%, caused this difference. AUDIT-positive seizure patients had a higher and more evenly distributed alcohol intake through the week, and the occurrence of seizures in this group did not differ significantly between days of the week. Alcohol consumption peaked 2 days prior to the onset of withdrawal seizures. The weekend drinking pattern was confirmed for all the study groups. Hazardous alcohol consumption preceded every third acute seizure, but was found in only one of eight outpatients with epilepsy. AUDIT-negative patients caused a peak of seizure admissions on Mondays, compared to Saturdays, with a diminishing trend through the week.
周末狂饮被认为是北欧国家酒精消费的一个主要特征。据报道，癫痫发作和中风等神经系统疾病与酒精中毒及戒断存在时间上的关联。我们想要研究工作日酒精消费的差异与这些疾病中神经系统症状发作的关系。该研究纳入了因癫痫发作入院的连续患者（n = 142）和缺血性中风患者（n = 91）。对照组为连续住院的坐骨神经痛患者（n = 181）、癫痫门诊患者（n = 91）和健康受试者（n = 254）。记录入院前8天内患者每日的酒精摄入量。在酒精使用障碍识别测试（AUDIT）中得分≥8（AUDIT阳性）的有危险饮酒行为的受试者发生的癫痫发作被认为与酒精使用有关。狂饮者的定义为在过去3天中至少有1天男性酒精摄入量≥6标准单位，女性≥4标准单位。35%的癫痫患者AUDIT阳性，相比之下，中风和坐骨神经痛患者的这一比例分别为18%和16%，癫痫门诊患者和健康对照组分别为12%和13%。23%的癫痫患者是狂饮者，而在其他组中，这一比例不超过10%。在所有组中，酒精消费在周六达到峰值。与周六相比，周一发生的癫痫发作更多，且在一周内呈递减趋势。然而，AUDIT阴性的癫痫患者导致了这种差异，其中只有5%的患者有狂饮行为。AUDIT阳性的癫痫患者在一周内酒精摄入量更高且分布更均匀，该组癫痫发作的发生在一周内各天之间没有显著差异。戒断性癫痫发作开始前2天酒精消费达到峰值。所有研究组都证实了周末饮酒模式。每三次急性癫痫发作中就有一次之前存在危险饮酒行为，但在八名癫痫门诊患者中仅发现一例。与周六相比，AUDIT阴性患者导致周一癫痫发作入院人数达到峰值，且在一周内呈递减趋势。
