斑秃中的人类白细胞抗原

HLA in alopecia areata.

作者信息

Kavak A, Baykal C, Ozarmağan G, Akar U

机构信息

Departments of Dermatology and Medical Biology, Medical Faculty, Istanbul University, Istanbul, Turkey.

出版信息

Int J Dermatol. 2000 Aug;39(8):589-92. doi: 10.1046/j.1365-4362.2000.00921.x.

DOI:10.1046/j.1365-4362.2000.00921.x

PMID:10971726

Abstract

BACKGROUND

The aim of this study was to investigate the human leukocyte antigen (HLA) characteristics of Turkish alopecia areata patients, and the correlation of the HLA profile with age of onset, severity and duration of the disease, presence of ophiasis, and family history.

METHODS

A total of 88 patients with alopecia areata, alopecia totalis, or alopecia universalis were compared with 100 healthy controls. HLA typing was performed by the Terasaki microlymphocytotoxicity method.

RESULTS

The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HLA-DQ3 was significantly higher in patients than in controls. HLA-DR16 was significantly less common in patients than in the control group, and we concluded that this allele might have a protective role for alopecia areata. Juvenile onset and severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA profile was independent of the existence of long-standing disease, presence of ophiasis, and a positive family history.

CONCLUSIONS

In HLA-alopecia areata association, ethnic differences may play a role.

摘要

背景

本研究旨在调查土耳其斑秃患者的人类白细胞抗原（HLA）特征，以及HLA谱与发病年龄、疾病严重程度和病程、匐行性斑秃的存在情况及家族史之间的相关性。

方法

将总共88例斑秃、全秃或普秃患者与100名健康对照者进行比较。采用Terasaki微量淋巴细胞毒性方法进行HLA分型。

结果

患者中HLA-A1、HLA-B62(15)、HLA-DQ1和HLA-DQ3的频率显著高于对照组。HLA-DR16在患者中的出现频率显著低于对照组，我们得出结论，该等位基因可能对斑秃具有保护作用。青少年发病和严重受累分别与HLA-Cw7和HLA-DR1相关。HLA谱与疾病的长期存在、匐行性斑秃的存在及家族史阳性无关。