Chua K B, Lam S K, Sazaly A B, Lim S T, Paranjothy M
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Med J Malaysia. 1999 Mar;54(1):32-6.
A provisional clinical diagnosis of exanthem subitum was made in six febrile infants seen in the Paediatric Unit of Assunta Hospital, Petaling Jaya, Malaysia with uvulo-palatoglossal junctional ulcers prior to the eruption of maculopapular rash. On follow-up, all six infants developed maculopapular rash with the subsidence of fever at the end of the fourth febrile day. Human herpesvirus 6 was isolated from the peripheral blood mononuclear cells during the acute phase of the illness and HHV 6 specific genome was also detected in these cells by nested polymerase chain reaction. All the six infants showed seroconversion for both specific IgG and IgM to the isolated virus. This study suggests that the presence of uvulo-palatoglossal junctional ulcers could be a useful early clinical sign of exanthem subitum due to human herpesvirus 6.
在马来西亚八打灵再也阿孙塔医院儿科病房就诊的6名发热婴儿中，在斑丘疹出现之前，根据悬雍垂腭舌交界处溃疡做出了幼儿急疹的临时临床诊断。随访发现，所有6名婴儿在发热的第4天末出现斑丘疹且热退。在疾病急性期从外周血单个核细胞中分离出人类疱疹病毒6型，并且通过巢式聚合酶链反应在这些细胞中也检测到HHV 6特异性基因组。所有6名婴儿针对分离出的病毒的特异性IgG和IgM均出现血清转化。本研究提示，悬雍垂腭舌交界处溃疡可能是人类疱疹病毒6型所致幼儿急疹的一个有用的早期临床征象。
