Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T, Kajita Y, Ozaki T
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Pediatrics. 1994 Jan;93(1):104-8.
To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study.
Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both.
The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4 degrees C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions.
Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.
在一项大规模研究中阐明原发性人疱疹病毒6型（HHV - 6）感染（幼儿急疹）患者的临床特征。
对176例最初怀疑为幼儿急疹且后来确诊为原发性HHV - 6感染的婴儿的临床体征和症状进行分析。通过从血液中分离出病毒、病毒中和抗体滴度显著升高或两者兼而有之来证实感染。
全年均有原发性HHV - 6感染发生，其中男孩94例，女孩82例（平均年龄7.3个月）。98%的患儿出现发热（平均最高体温39.4摄氏度），持续4.1天。98%的患儿出现斑疹或丘疹，主要出现在面部、躯干或两者皆有，大多在热退时出现，持续3.8天。其他临床表现如下：68%有轻度腹泻，30%有眼睑水肿，65%咽部有红斑丘疹，50%有咳嗽，31%有轻度颈部淋巴结肿大。26%的患儿前囟饱满，8%有惊厥。
病毒学确诊的幼儿急疹患者的临床特征与在发现HHV - 6之前所描述的特征相似。
