Halder D, Haque M E, Zabidi M H, Kamaruzzaman A
Rustaq Hospital, Rustaq, Sultanate of Oman.
Med J Malaysia. 1999 Mar;54(1):52-7.
From January to December 1992, 92 babies weighing 1000-1499 gm here to referred as very low birth weight (VLBW) were admitted to NICU (Neonatal Intensive Care Unit), Hospital University Sains Malaysia (HUSM). Sixty babies were inborn giving a VLBW rate of 7.5 per 1000 live births. Incidence of nosocomial sepsis was 32.6% (30/92) of whom 43.3% (13/30) died. Eighty percent (24/30) of the septic babies had blood culture positive for gram negative organisms of which 40% (12/30) were sensitive only to imipenem. Ventilator support within 24 hours of life was required in 41.3% (38/94) babies of whom 42% (16/38) babies developed nosocomial sepsis. Delayed initiation of feeding was significantly associated with nosocomial sepsis. A strict asepsis policy and early feeding of the VLBW infant are essential components of any strategy to prevent of sepsis due to nosocomial infection.
1992年1月至12月，马来西亚理科大学医院新生儿重症监护病房（NICU）收治了92名体重在1000 - 1499克之间的婴儿，此处将其称为极低出生体重（VLBW）儿。60名婴儿为顺产，VLBW发生率为每1000例活产中有7.5例。医院感染性败血症的发生率为32.6%（30/92），其中43.3%（13/30）死亡。80%（24/30）的败血症婴儿血培养革兰阴性菌阳性，其中40%（12/30）仅对亚胺培南敏感。41.3%（38/94）的婴儿在出生后24小时内需要呼吸机支持，其中42%（16/38）的婴儿发生了医院感染性败血症。延迟开始喂养与医院感染性败血症显著相关。严格的无菌政策和对极低出生体重儿的早期喂养是预防医院感染所致败血症的任何策略的重要组成部分。
