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用促黄体生成素释放激素的肽类似物抑制排卵前动情前期促性腺激素高峰、排卵和妊娠。

Ihibition of the pre-ovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone.

作者信息

Corbin A, Beattie C W

出版信息

Endocr Res Commun. 1975;2(1):1-23. doi: 10.3109/07435807509053836.

DOI:10.3109/07435807509053836
PMID:1097236
Abstract

D-[PHE]-2-D[ALA]-6-LRH (Wy-18,185), an analogue of synthetic hypothalamic LRH, was evaluated for its anti-fertility properties. The compound dampens the preovulatory proestrous surge of serum LH and FSH in rats, is an active anti-ovulatory agent in both rats and rabbits and prevents pregnancy when administered pre-coitally to rats. Additionally, the compound suppresses the ovulatory event in rats only during the cycle in which it is acutely administered, does not interfere with the rat vaginal cycle and is devoid of any effects on body, ovarian and uterine weights when given acutely. The compound is a moderate LRH agonist in rats but does not induce ovulation in rats or rabbits.

摘要

D-[苯丙氨酸]-2-D[丙氨酸]-6-促性腺激素释放激素（Wy-18,185），一种合成下丘脑促性腺激素释放激素的类似物，对其抗生育特性进行了评估。该化合物可抑制大鼠血清促黄体生成素（LH）和促卵泡生成素（FSH）排卵前的发情前期激增，在大鼠和兔子中均为有效的抗排卵剂，在大鼠交配前给药可防止怀孕。此外，该化合物仅在急性给药的周期中抑制大鼠的排卵事件，不干扰大鼠的阴道周期，急性给药时对体重、卵巢和子宫重量无任何影响。该化合物在大鼠中是一种中度促性腺激素释放激素激动剂，但不会诱导大鼠或兔子排卵。

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