Chihara K, Kato Y, Ohgo S, Imura H
Endocrinol Jpn. 1975 Apr;22(2):105-9. doi: 10.1507/endocrj1954.22.105.
In intact urethane-anesthetized rats, plasma growth hormone (GH) levels were low but increased significantly following intravenous injection of chlorpromazine. Plasma GH levels were significantly elevated in rats with hypothalamic cuts such as complete deafferentiation, anterior cut and antero-lateral cut, whereas plasma GH levels in rats with posterior cut or postero-lateral cut were not significantly different from those in rats with sham-operation. Intravenous injection of chlorpromazine caused an increase of plasma GH in rats with any type of hypothalamic cut. However, the maximum increments of plasma GH following chlorpromazine were larger in rats with antero-lateral cut and smaller in rats with posterior cut than in rats with sham-operation. These results suggest that extrahypothalamic inhibiting and stimulating neurons influence the regulatory mechanism of rat GH secretion through anterior and posterior routes to the hypothalamus respectively.
在完整的、经氨基甲酸乙酯麻醉的大鼠中，血浆生长激素（GH）水平较低，但静脉注射氯丙嗪后显著升高。在下丘脑切断的大鼠中，如完全去传入、前侧切断和前外侧切断，血浆GH水平显著升高，而在后侧切断或后外侧切断的大鼠中，血浆GH水平与假手术大鼠无显著差异。静脉注射氯丙嗪会使任何类型下丘脑切断的大鼠血浆GH升高。然而，与假手术大鼠相比，氯丙嗪注射后血浆GH的最大增量在前外侧切断的大鼠中较大，在后侧切断的大鼠中较小。这些结果表明，下丘脑外抑制性和刺激性神经元分别通过下丘脑的前、后途径影响大鼠GH分泌的调节机制。
