氯丙嗪抑制大鼠的间歇性生长激素分泌。

Chlorpromazine inhibits episodic growth hormone secretion in the rat.

作者信息

Wakabayashi I, Kanda M, Miki N, Demura R, Shizume K

出版信息

Acta Endocrinol (Copenh). 1979 Jul;91(3):428-36. doi: 10.1530/acta.0.0910428.

DOI:10.1530/acta.0.0910428

Abstract

Effects of chlorpromazine (CPZ) on plasma GH and prolactin levels were observed in conscious rats provided with chronic indwelling right atrial cannulae. The administration of CPZ (200 micrograms/100 g b.w. iv) suppressed episodic plasma GH burst and resulted in significant elevations of plasma prolactin levels. These were also observed in rats in which two types of hypothalamic deafferentation, i.e. anterior and complete, had been carried out. The data suggest that CPZ acts within the medial basal hypothalamus and inhibits episodic plasma GH secretion. In addition, it is inferred that catecholamines are involved in the generation of episodic plasma GH burst.

摘要

在有意识的、右心房长期留置插管的大鼠中观察了氯丙嗪（CPZ）对血浆生长激素（GH）和催乳素水平的影响。静脉注射CPZ（200微克/100克体重）可抑制血浆GH的阵发性脉冲，并导致血浆催乳素水平显著升高。在进行了两种类型下丘脑去传入手术（即前部去传入和完全去传入）的大鼠中也观察到了这些结果。数据表明，CPZ作用于下丘脑内侧基底部并抑制血浆GH的阵发性分泌。此外，据推测儿茶酚胺参与了血浆GH阵发性脉冲的产生。