Moore K B, McKenna K, Osman M, Tormey W P, McDonald D, Thompson C J
Department of Diabetes and Endocrinology, Diabetes Day Centre, Beaumont Hospital, Dublin 9, Ireland.
Ir J Med Sci. 2007 Jul-Sep;176(2):67-73. doi: 10.1007/s11845-007-0030-1. Epub 2007 May 3.
Atrial natriuretic peptide (ANP) is elevated in patients with type-2 diabetes and microalbuminuria. The purpose of this study is to evaluate if ANP increases Urinary Albumin Eaxcretion Rate (UAER) in type-2 diabetes.
Eight normoalbuminuric diabetic subjects underwent a randomised single blind study of 60 min intravenous infusion of ANP or vehicle. Eight non-diabetic controls underwent ANP infusion alone. Seven normoalbuminuric type-2 diabetes subjects received further ANP infusions during euglycaemia and during hyperglycaemia.
ANP increased urinary sodium (191.3 +/- 80.7 to 529.2 +/- 263.4 mumol/min, mean +/- SD, and P < 0.001) and UAER (72.2 +/- 73.4 to 224.9 +/- 182.9.5 mug/min, and P < 0.01) in diabetic subjects. In controls, UAER did not change significantly (P = 0.16); however, the natriuretic response to ANP was similar to diabetic subjects (P = 0.98). Hyperglycaemic did not enhance the albuminuric response to ANP (P = 0.88).
ANP increases UAER in normoalbuminuric type-2 diabetic subjects.
2型糖尿病合并微量白蛋白尿患者的心房利钠肽（ANP）水平升高。本研究旨在评估ANP是否会增加2型糖尿病患者的尿白蛋白排泄率（UAER）。
8名尿白蛋白正常的糖尿病受试者进行了一项随机单盲研究，静脉输注ANP或赋形剂60分钟。8名非糖尿病对照者仅接受ANP输注。7名尿白蛋白正常的2型糖尿病受试者在血糖正常和高血糖期间接受了进一步的ANP输注。
在糖尿病受试者中，ANP增加了尿钠排泄（从191.3±80.7增至529.2±263.4μmol/分钟，均值±标准差，P<0.001）以及UAER（从72.2±73.4增至224.9±182.95μg/分钟，P<0.01）。在对照者中，UAER无显著变化（P=0.16）；然而，对ANP的利钠反应与糖尿病受试者相似（P=0.98）。高血糖并未增强对ANP的蛋白尿反应（P=0.88）。
ANP可增加尿白蛋白正常的2型糖尿病受试者的UAER。
