伴有神经内分泌分化的乳腺黏液癌。

Mucinous carcinoma of the breast with neuroendocrine differentiation.

作者信息

Nakagawa H, Shikata N, Senzaki H, Uemura Y, Inoue T, Kashu S, Tsubura A

机构信息

Department of Pathology, Kansai Medical University, Moriguchi, Japan.

出版信息

Pathol Int. 2000 Aug;50(8):644-8. doi: 10.1046/j.1440-1827.2000.01095.x.

DOI:10.1046/j.1440-1827.2000.01095.x

PMID:10972863

Abstract

A case of mucinous carcinoma of the breast with neuroendocrine differentiation in an 89-year-old woman is presented. The patient presented with a rapidly growing right breast mass, which she had had for 2-3 years. The tumor, 15 x 8 x 5 cm, was located mainly in the upper outer quadrant. Light microscopy revealed a pure mucinous carcinoma of type B. Neuroendocrine differentiation was demonstrated by Grimelius stain and chromogranin A, as well as the presence of neurosecretory granules. The breast cancer cells were of luminal origin and had dedifferentiated to attain neuroendocrine properties.

摘要

本文报告了一例89岁女性乳腺黏液癌伴神经内分泌分化的病例。患者表现为右乳肿块迅速增大，已存在2至3年。肿瘤大小为15×8×5cm，主要位于外上象限。光镜检查显示为B型纯黏液癌。Grimelius染色、嗜铬粒蛋白A以及神经分泌颗粒的存在证实了神经内分泌分化。乳腺癌细胞起源于管腔上皮，已发生去分化以获得神经内分泌特性。