Khurana K K, Tornos C, Silva E G
Department of Pathology, University of Texas Medical School at Houston.
Arch Pathol Lab Med. 1994 Oct;118(10):1032-4.
We describe a rare case of a neuroendocrine carcinoma of the ovary in a 22-year-old woman who presented with abdominal pain and a pelvic mass. Exploratory laparotomy revealed a right ovarian tumor weighing 2100 g. A right salpingo-oophorectomy and an appendectomy were performed. There was no evidence intraoperatively or postoperatively of metastatic disease. Microscopic examination of the ovary revealed solid nests of tumor cells with a neuroendocrine appearance, high mitotic rate, necrosis, and vascular invasion; the tumor was associated with a predominantly borderline mucinous neoplasm with a small focus of mucinous carcinoma. Neuroendocrine differentiation was confirmed by Grimelius stains, immunohistochemical assays (chromogranin), and electron microscopy. The appendix was histologically unremarkable. The patient received a course of chemotherapy; 3 months after completing chemotherapy, she developed multiple liver metastases and died of disease a week later. To our knowledge, this case report is the second one involving a primary neuroendocrine carcinoma of the ovary occurring in association with a mucinous neoplasm. Mixed mucinous and neuroendocrine carcinoma of the ovary may represent a rare neoplasm with extremely aggressive behavior.
我们报告一例罕见的22岁女性卵巢神经内分泌癌病例，该患者表现为腹痛和盆腔肿块。剖腹探查发现右侧卵巢肿瘤重达2100克。行右侧输卵管卵巢切除术及阑尾切除术。术中及术后均未发现转移病灶。卵巢显微镜检查显示肿瘤细胞呈实性巢状，具有神经内分泌外观、高有丝分裂率、坏死及血管侵犯；该肿瘤与主要为交界性黏液性肿瘤伴小灶黏液癌相关。通过 Grimelius 染色、免疫组化检测（嗜铬粒蛋白）及电子显微镜检查证实了神经内分泌分化。阑尾组织学检查未见异常。患者接受了一个疗程的化疗；完成化疗3个月后，她出现多处肝转移，一周后死于该疾病。据我们所知本病例报告是第二例涉及原发性卵巢神经内分泌癌合并黏液性肿瘤的病例。卵巢黏液性和神经内分泌混合癌可能是一种罕见肿瘤，具有极其侵袭性的行为。
