Boos W, Böhm A
Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Trends Genet. 2000 Sep;16(9):404-9. doi: 10.1016/s0168-9525(00)02086-2.
The regulation of the maltose system in Escherichia coli has traditionally been viewed as a simple positive feedback loop. Today, we know that there are cross connections to several, seemingly unrelated, metabolic pathways. MalT, the central activator of the mal genes, is the key element in this complex regulatory network and integrates the different signals to give an appropriate transcriptional response.
传统上,大肠杆菌中麦芽糖系统的调控被视为一个简单的正反馈回路。如今,我们知道它与几条看似不相关的代谢途径存在交叉联系。MalT是mal基因的核心激活因子,是这个复杂调控网络中的关键元件,它整合不同信号以产生适当的转录反应。