Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Max-Planck Institute for Plant Breeding Research, Cologne, 50829, Germany.
Sci China Life Sci. 2020 Sep;63(9):1303-1316. doi: 10.1007/s11427-019-1687-6. Epub 2020 Jun 28.
NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.
NLRs 构成了动植物细胞内的免疫受体。直接或间接的配体识别导致寡聚 NLR 复合物的形成，从而介导免疫信号转导。在过去的 20 年中，我们对 NLR 信号转导的理解取得了快速进展。结构和生化研究深入了解了几种 NLR 的自身抑制、配体识别和抵抗体/炎症小体形成的分子基础。在这篇综述中，我们总结了这些研究，重点介绍了 NLR 的结构方面。我们还讨论了植物和动物 NLR 在作用机制方面的相似性和差异性，以及这些现有知识如何为其他 NLR 的信号转导机制提供启示。
