骨矿物质密度、维生素D与抗惊厥治疗
Bone mineral density, vitamin D and anticonvulsant therapy.
作者信息
Filardi S, Guerreiro C A, Magna L A, Marques Neto J F
机构信息
Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazil.
出版信息
Arq Neuropsiquiatr. 2000 Sep;58(3A):616-20. doi: 10.1590/s0004-282x2000000400003.
UNLABELLED
The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy.
METHODS
Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1, 25-dihydroxycholecalciferol.
RESULTS
No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy.
CONCLUSION
Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.
未标注
本研究的目的是评估接受慢性抗惊厥治疗的患者的骨矿物质密度和维生素D代谢情况。
方法
对69名接受慢性抗惊厥治疗至少5年的男性门诊患者进行研究，并将他们与30名健康对照者进行比较。测量了骨矿物质密度以及血清钙、离子钙、碱性磷酸酶、甲状旁腺激素、25-羟胆钙化醇和1,25-二羟胆钙化醇的水平。
结果
患者和对照者之间在骨矿物质密度、维生素D血清水平和完整甲状旁腺激素方面未观察到差异。骨矿物质密度与慢性抗惊厥治疗无关。
结论
那些接受慢性抗惊厥治疗且生活在低纬度地区的成年患者具有正常的骨矿物质密度和维生素D血清水平。
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