Liu Yuanyuan, Gong Chao, Li Jiawei, Ning Xin, Zeng Pei, Wang Luchuan, Lian Beibei, Liu Jiahao, Fang Liya, Guo Jin
College of Rehabilitation Medicine, Jiamusi University, Jiamusi, China.
Jiamusi University Affiliated No. 3 Hospital, Jiamusi, China.
Front Nutr. 2024 Aug 30;11:1439279. doi: 10.3389/fnut.2024.1439279. eCollection 2024.
The prevalence of vitamin D deficiency and vitamin D levels in patients with epilepsy (PWE) were systematically evaluated, and the differences between subgroups were analyzed.
We identified all articles investigating the prevalence of vitamin D deficiency in patients with epilepsy from the database established in March 2024 from PubMed, Web of Science, and Embase. We divided them into anti-seizure medication (ASM) interventions and non-ASM interventions according to whether or not someone used ASM.
A total of 68 articles were included. The prevalence of newly diagnosed epilepsy was 50.2% (95% CI: 38.7-61.7%), and the prevalence after ASM intervention was 47.9% (95% CI: 40-55.9%), including 7,070 patients with epilepsy. Subgroup and meta-regression analyses were performed according to the diagnostic criteria, economic development level, region, age, ASM treatment, and other factors. The results showed that the differences were not significant. In addition, the vitamin D content of epilepsy patients (18.719 ng/mL) was lower than that of healthy people (20.295 ng/mL).
The prevalence of vitamin D deficiency in patients with epilepsy is very high. Still, the related factors have little effect on the high prevalence of vitamin D in epilepsy, and ASM intervention can reduce the vitamin D content in patients with epilepsy. Therefore, it is emphasized that monitoring vitamin D levels is part of the routine management of patients with epilepsy.
The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO). (registration number CRD42023493896). https://www.crd.york.ac.uk/PROSPERO/ # myprospero.
系统评估癫痫患者（PWE）中维生素D缺乏症的患病率和维生素D水平，并分析亚组之间的差异。
我们从2024年3月建立的数据库中，通过PubMed、Web of Science和Embase检索了所有调查癫痫患者维生素D缺乏症患病率的文章。根据是否使用抗癫痫药物（ASM）将它们分为ASM干预组和非ASM干预组。
共纳入68篇文章。新诊断癫痫的患病率为50.2%（95%置信区间：38.7-61.7%），ASM干预后的患病率为47.9%（95%置信区间：40-55.9%），包括7070例癫痫患者。根据诊断标准、经济发展水平、地区、年龄、ASM治疗等因素进行亚组和Meta回归分析。结果显示差异无统计学意义。此外，癫痫患者的维生素D含量（18.719 ng/mL）低于健康人（20.295 ng/mL）。
癫痫患者维生素D缺乏症的患病率非常高。然而，相关因素对癫痫患者维生素D高患病率的影响较小，ASM干预可降低癫痫患者的维生素D含量。因此，强调监测维生素D水平是癫痫患者常规管理的一部分。
该方案已在国际系统评价前瞻性注册库（PROSPERO）注册。（注册号CRD42023493896）。https://www.crd.york.ac.uk/PROSPERO/ # myprospero
