Raskin P
Metabolism. 1979 Jul;28(7):780-96. doi: 10.1016/0026-0495(79)90186-0.
For more than half a century the management of hyperglycemia in diabetes mellitus has included rigid diets and intermittent subcutaneous insulin administration. These methods have been totally unsuccessful in restoring glucose homeostasis to normal in most diabetic patients. This review focuses on techniques that offer promise as alternatives or adjuncts to the current modalities of treatment. Specific areas discussed include pancreatic transplantation, islet cell transplantation, artificial beta cell devices, and the glucagon-suppressing agent somatostatin. Although many of these show promise for the future, a cure for the metabolic abnormalities of diabetes is not imminent.
半个多世纪以来，糖尿病高血糖的管理方法包括严格的饮食控制和间歇性皮下注射胰岛素。在大多数糖尿病患者中，这些方法在使葡萄糖稳态恢复正常方面完全失败。本综述重点关注有望替代或辅助当前治疗方式的技术。讨论的具体领域包括胰腺移植、胰岛细胞移植、人工β细胞装置以及胰高血糖素抑制药物生长抑素。尽管其中许多技术在未来显示出前景，但糖尿病代谢异常的治愈方法并非指日可待。
