Long S F, Wilson M C, Davis W M
Department of Pharmaceutical Sciences, School of Pharmacy, Southwestern Oklahoma State Unversity, Weatherford, OK 73096, USA.
Neuropharmacology. 2000 Sep;39(12):2442-7. doi: 10.1016/s0028-3908(00)00061-7.
Use and abuse of various controlled substances in recent years has reached alarming levels. Among these are cocaine and anabolic steroids. The two contrasting types of drug have common sites of action within the limbic system of the central nervous system. The ability of cocaine to provoke seizures is well documented, and sex hormones also have been shown to alter seizure types and characteristics. This project studied the consequences of co-administration of cocaine and a representative anabolic-androgenic steroid, nandrolone decanoate. Specifically, the effects of nandrolone on cocaine-induced kindling of seizures were examined. Nandrolone was shown to increase seizure rate when given in high (20mg twice weekly) intermittent doses. No statistically significant differences were observed with low (2mg) daily doses of nandrolone. The results support the hypothesis that an androgen may interact so as to modify the pattern of cocaine-related kindling. However, the potential of either pharmacodynamic and/or pharmacokinetic mechanism(s) for this interaction exists, and the nature of these interactions remains to be fully elucidated.
近年来，各种管制药品的使用和滥用已达到惊人的程度。其中包括可卡因和合成代谢类固醇。这两种截然不同的药物在中枢神经系统的边缘系统中有共同的作用部位。可卡因诱发癫痫发作的能力已有充分记录，并且性激素也已被证明会改变癫痫发作的类型和特征。本项目研究了可卡因与一种具有代表性的合成代谢雄激素类固醇——癸酸诺龙联合使用的后果。具体而言，研究了诺龙对可卡因诱发癫痫发作点燃效应的影响。结果表明，高剂量（每周两次，每次20毫克）间歇性给予诺龙时会增加癫痫发作率。低剂量（每日2毫克）诺龙未观察到统计学上的显著差异。这些结果支持了雄激素可能相互作用从而改变可卡因相关点燃模式的假说。然而，这种相互作用存在药效学和/或药代动力学机制的可能性，并且这些相互作用的性质仍有待充分阐明。
