Kindlundh A M, Lindblom J, Bergström L, Wikberg J E, Nyberg F
Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Box 591 Biomedicum, S-751 24 Uppsala, Sweden.
Eur J Neurosci. 2001 Jan;13(2):291-6. doi: 10.1046/j.0953-816x.2000.01402.x.
In recent years a male group of anabolic-androgenic steroid misusers has been identified to share socio-demographic and personality related background factors with misusers of psychotropic substances, as well as being involved in habits of multiple drug use. The present study aimed to assess whether anabolic-androgenic steroids (AAS) would affect the density of the dopamine receptors in areas implicated in reward and behaviour in the male rat brain. The effects of 2 weeks of treatment with i.m. injections of nandrolone decanoate (15 mg/kg/day) on the expression of the D(1)-like and D(2)-like receptors were evaluated by autoradiography. Specific binding of D(1)-like receptors was significantly down regulated in the caudate putamen, the nucleus accumbens core and shell. D(2)-like receptor densities were down regulated in the nucleus accumbens shell, but up regulated in the caudate putamen, the nucleus accumbens core and the ventral tegmental area. These results are compatible with nandrolone induced neuroadaptive alterations in dopamine circuits associated with motor functions and behavioural paradigms known to be affected following AAS misuse.
近年来，已确认有一群滥用合成代谢雄激素类固醇的男性，他们在社会人口统计学和与人格相关的背景因素方面与滥用精神药物者相同，并且还存在多种药物滥用习惯。本研究旨在评估合成代谢雄激素类固醇（AAS）是否会影响雄性大鼠大脑中与奖赏和行为相关区域的多巴胺受体密度。通过放射自显影法评估了肌肉注射癸酸诺龙（15毫克/千克/天）两周对D（1）样和D（2）样受体表达的影响。在尾状壳核、伏隔核核心和壳中，D（1）样受体的特异性结合显著下调。D（2）样受体密度在伏隔核壳中下调，但在尾状壳核、伏隔核核心和腹侧被盖区中上调。这些结果与诺龙诱导的多巴胺回路神经适应性改变相一致，这些回路与已知在滥用AAS后会受到影响的运动功能和行为模式有关。
