Johnsson A A, Jacobsson M, Granström G, Johansson C B, Strid K, Turesson I
Department of Radiology, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden.
Int J Radiat Oncol Biol Phys. 2000 Sep 1;48(2):555-63. doi: 10.1016/s0360-3016(00)00638-6.
To analyze the effect of irradiation on cancellous bone healing at different times after irradiation and to study if hyperbaric oxygen therapy (HBO) would affect the bone healing capacity, when delivered directly after irradiation.
Rabbits were given a single dose of 15 Gy (60)Co radiation to one hind leg, the other hind leg serving as control. A standardized defect through the femoral metaphysis of the rabbits was created by a trephine drill biopsy at different times after irradiation. New bone formation in the defect was evaluated by a new biopsy through the previous defect after a healing time of 8 weeks. The mineral contents of the biopsies were analyzed by microradiography and microdensitometry.
There was a large variation in the bone-forming capacity expressed as bone mineral content between the animals. No statistically significant differences could be detected regarding the effect of irradiation, HBO, or delayed surgery. Qualitative histology revealed more pronounced inflammation, fibrosis, and bone resorption in the irradiated bone.
No definite conclusions can be drawn from the results of this study, however it might be hypothesized that cancellous bone recovers faster than cortical bone from radiation trauma.
分析照射对照射后不同时间松质骨愈合的影响，并研究高压氧治疗（HBO）在照射后立即进行时是否会影响骨愈合能力。
对兔的一条后腿给予单次15 Gy（60）Co辐射剂量，另一条后腿作为对照。在照射后的不同时间，通过环钻活检在兔股骨近端干骺端制造标准化缺损。在愈合8周后，通过对先前缺损部位进行新的活检来评估缺损部位的新骨形成情况。通过显微放射照相术和显微密度测定法分析活检组织的矿物质含量。
不同动物之间以骨矿物质含量表示的骨形成能力差异很大。关于照射、HBO或延迟手术的影响，未检测到统计学上的显著差异。定性组织学显示，照射骨中的炎症、纤维化和骨吸收更为明显。
本研究结果无法得出明确结论，然而可以推测，松质骨从辐射损伤中恢复的速度比皮质骨快。
