Wang C F, Lasley B L, Yen S S
J Clin Endocrinol Metab. 1975 Jul;41(1):41-3. doi: 10.1210/jcem-41-1-41.
The role of estradiol in modulating pituitary gonadotropin release in the human male was studied by evaluating the effects of clomiphene on the pituitary gonadotropin response to synthetic LRF (150 mug) in 6 eugonadal men. Administration of clomiphene (100 mg single daily dose time 5 days) induced a significant elevation of the basal levels of LH, FSH, estradiol and testosterone. However, the pituitary release of LH and FSH in response to LRF was markedly diminished by the clomiphene treatment. This finding suggests that in men, as in women, endogenous estradiol provides feedback regulation of gonadotropin output by the pituitary.
通过评估克罗米芬对6名性腺功能正常男性垂体促性腺激素对合成LRF（150微克）反应的影响，研究了雌二醇在调节男性垂体促性腺激素释放中的作用。给予克罗米芬（每日单次剂量100毫克，共5天）可使LH、FSH、雌二醇和睾酮的基础水平显著升高。然而，克罗米芬治疗使垂体对LRF反应时LH和FSH的释放明显减少。这一发现表明，在男性中，如同在女性中一样，内源性雌二醇对垂体促性腺激素的分泌提供反馈调节。
