Sutow W W, Sullivan M P, Wilbur J R, Cangir A
J Clin Pharmacol. 1975 Jul;15(7):530-3. doi: 10.1002/j.1552-4604.1975.tb01476.x.
Twelve patients with osteosarcoma but without metastases were treated with adjuvant chemotherapy following surgical amputation for the primary lesion. The chemotherapy regimen utilized vincristine, actinomycin D, and cyclophosphamide (in high pulse doses) administered intermittently over a 55-week period. Four of the 12 patients (33%) are surviving with no evidence of disease 54 months or longer from time of surgery. These results suggest that the 3-drug combination used in this study should be considered in the formulation of future multidrug adjuvant chemotherapy programs in the management of patients with osteosarcoma.
12例骨肉瘤且无转移的患者在对原发性病灶进行手术截肢后接受了辅助化疗。化疗方案采用长春新碱、放线菌素D和环磷酰胺（高脉冲剂量），在55周的时间内间歇性给药。12例患者中有4例（33%）自手术时起已存活54个月或更长时间，且无疾病迹象。这些结果表明，在制定未来骨肉瘤患者多药辅助化疗方案时应考虑本研究中使用的三联药物组合。
