Sutow W W, Sullivan M P, Fernbach D J, Cangir A, George S L
Cancer. 1975 Nov;36(5):1598-602. doi: 10.1002/1097-0142(197511)36:5<1598::aid-cncr2820360511>3.0.co;2-n.
A four-drug adjuvant chemotherapy regimen (CONPADRI-I) was utilized in the primary treatment of 18 children with osteogenic sarcoma. All patients had surgical amputation for the primary lesion. The children then received cyclophosphamide, vincristine, melphalan, and adriamycin in defined combinations intermittently over a 72-week period. Of the 18 patients, 10 (55%) remain free of disease 24 months or longer from time of amputation.
一种四联辅助化疗方案（CONPADRI-I）用于18例骨肉瘤患儿的初始治疗。所有患者均接受了原发灶的手术截肢。这些患儿随后在72周的时间里间歇性地接受了环磷酰胺、长春新碱、美法仑和阿霉素的特定组合治疗。18例患者中，10例（55%）自截肢后24个月或更长时间无疾病复发。
