Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats.

The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1--3.5 mg/kg, P2--35.0 mg/kg, P3--350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.