Furniss L, Burns A, Craig S K, Scobie S, Cooke J, Faragher B
Withington Hospital, Manchester.
Br J Psychiatry. 2000 Jun;176:563-7. doi: 10.1192/bjp.176.6.563.
Older people in nursing and residential homes often have complex disabilities and behavioural disturbances. Recent publicity has highlighted the dangers of medication in this group, and controls over prescribing have been suggested.
To investigate the effect of a review of medication by a pharmacist.
An 8-month prospective trial of an active medication review by a pharmacist was carried out on 330 residents in nursing homes in Manchester.
The intervention group experienced greater deterioration in cognitive function and behavioural disturbance than the control group, but the changes in depression and quality of life were similar for both groups. The number of drugs prescribed fell in the intervention group, but not in the control group, with a corresponding saving in drug costs. The number of deaths was significantly smaller in the intervention homes during the intervention period (4 v. 14) but not overall during the study period as a whole (26 v. 28).
This clinical intervention reduced the number of medicines prescribed to elderly people in nursing homes, with minimal impact on their morbidity and mortality.
养老院中的老年人常常存在复杂的残疾问题和行为障碍。最近的宣传突出了该群体用药的危险性，并有人建议对处方进行管控。
调查药剂师进行药物审查的效果。
对曼彻斯特养老院的330名居民进行了为期8个月的药剂师主动药物审查前瞻性试验。
干预组在认知功能和行为障碍方面的恶化程度比对照组更大，但两组在抑郁和生活质量方面的变化相似。干预组的处方药物数量减少，而对照组未减少，相应地节省了药物成本。干预期间，干预养老院的死亡人数显著较少（4例对14例），但在整个研究期间总体上没有差异（26例对28例）。
这种临床干预减少了养老院老年人的处方药物数量，对其发病率和死亡率的影响最小。
