Smith H W, Huggins M B
J Gen Microbiol. 1975 Jul;89(1):133-6. doi: 10.1099/00221287-89-1-133.
Groups of chickens were vaccinated intravenously with live cultures of Escherichia coli K12 possessing transfer factors F, I, A2 or no transfer factor (Tra-minus) and their immunity challenged by injecting them intravenously with an F-plus strain of Salmonella heidelberg or an F-plus or I-plus strain of Salmonella typhimurium. Compared with the Tra-minus strain, vaccination with the F-plus, but not the I-plus or A2-plus, K12 strain significantly reduced the mortality rate caused by the F-plus salmonella strains; vaccination with the I-plus or A2-plus, but not the F-plus, K12 strain significantly reduced the mortality rate caused by the I-plus salmonella strain.
将携带转移因子F、I、A2或无转移因子（Tra阴性）的大肠杆菌K12活培养物静脉注射给几组鸡，然后通过静脉注射海德堡沙门氏菌F阳性菌株或鼠伤寒沙门氏菌F阳性或I阳性菌株来激发它们的免疫力。与Tra阴性菌株相比，用F阳性但不是I阳性或A2阳性的K12菌株进行疫苗接种可显著降低F阳性沙门氏菌菌株引起的死亡率；用I阳性或A2阳性但不是F阳性的K12菌株进行疫苗接种可显著降低I阳性沙门氏菌菌株引起的死亡率。
